Biophotonics Lab
Research Projects
Funding
In the biophotonics lab we use light to explore biological tissue. In particular, we are interested in non-invasive, localized functional imaging of the brain.
Acousto Optic Imaging
(in collaboration with Prof. Sergio Fantini@ Tufts U)
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We integrate light and sound to probe brain tissue and determine changes in perfusion.
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Acousto-optics enables to localize the measurement volume and measure changes in blood flow.
Functional Brain Imaging:
(in collaboration with Dr. Dmitry Patashov @ Waseda U and Dr. Dmitry Goldstein @ HIT)
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We use fNIRS (functional Near Infrared Spectroscopy) to study hemodynamic correlation maps.
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We develop new algorithms that can assess brain disorders (such as Major Depression or ADHD), based on non-invasive NIRS data.
Hemodynamic assessment of epileptic seizures:
(in collaboration with Dr. Mordekhay Medvedovsky @ Hadassah MC)
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We continuously measure changes in cerebral blood flow in patients with drug resistive epilepsy and determine spatial patterns of activity.
UMAMI - Ultrasound–Modulation Assisted Multiphoton Imaging
( in collaboration with Prof. Shy Shoham @ NYU Tech4Health)
Two-photon microscopy (TPM) inherently provides optical sectioning; however, it is still insufficient in preventing cross-talk between structures of interest. Acousto-optic modulation (AOM) of light has been demonstrated to improve the resolution and depth selectivity of optical imaging inside/through scattering tissue by locally modulating coherent light. We develop a novel use of AOM in multiphoton fluorescence generating a giant, orders-of-magnitude larger modulation and enabling improved contrast and details in TPM images.
Digital Holography
(In collaboration with Prof. Natan Shaked, Tel Aviv U) - check out this video animation
Wearable sensors
We also work on developing hardware and software for making personalized wearable sensors
Credit: Yael Avni
Detecting Epileptic seizures with EEG and Deep Learning algorithms
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We develop machine learning based algorithms for detecting epileptic seizures using wearable sensors
Wearable sensors for dysphagia management (MODAM)
(in collaboration with Dr. Hagit Shoffel-Havakuk and Saja Assi @ Rabin MC, and Dr. Avihai Ahaon, Dr. Heftsi Ragones, Dr. Jonathan Rubin and Yael Avni @HIT)
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We are developing new sensors and algorithms for extracting quantitative parameters from multi-modal sensors. We focus on a wearable sensor for patients with a swallowing disorder (dysphagia)